Currently, the following main strategies for FS treatment are applied, which are basically the same as those used for RA: nonsteroidal anti-inflammatory drugs and antirheumatic drugs (such as methotrexate, leflunomide, sulfasalazine, and hydroxychloroquine); Immune and biological agents (such as cyclophosphamide, tumor necrosis factor-α blocker, and rituximab); corticosteroids; granulocyte colony-stimulating factor; splenectomy; other (traditional Chinese medicine). Here, TNF is linked to rheumatoid arthritis.