Although there are case reports that the granulocyte colony-stimulating factor was effective for severe neutropenia treatment, currently, randomized clinical trials for the treatment of neutropenia and its infectious complications are lacking, and its reliability is, hence, questionable.[7] Splenectomy is the last treatment for patients with severe neutropenia and repeated FS infection, but its effectiveness is not long-lasting. This evidence concerns the gene CSF3 and neutropenia.