Plasma cell dyscrasias, including multiple myeloma and monoclonal gammopathies, can present with symmetric polyarthritis owing to mechanisms such as monoclonal light chain deposition in synovial tissue[30] or IL-6 overexpression.[32,41] B-cell lymphomas with pulmonary lymphoid granulomatosis may present as granulomatosis with polyangiitis, further complicating the diagnosis.[42] Consequently, the multifaceted mechanisms through which hematologic malignancies mimic rheumatic diseases pose a significant diagnostic challenge owing to their broad spectrum of clinical presentations. This evidence concerns the gene IL6 and monoclonal gammopathy.