The study by Liu examined the immune cells in the endometrium of PCOS women with IR, determining that CD56+ NK cells and CD163+ M2 macrophages were positively correlated with the quantitative insulin sensitivity index (QUICKI), indicating that there was an association between immune cells in the endometrium and IR.[5] Betatrophin therapy experiments in vitro and in vivo demonstrated that hepatocytes and macrophages interacted with cellular to regulate dystrophin levels in PCOS women with IR.[53]. This evidence concerns the gene CD163 and polycystic ovary syndrome.