FOXO-1 activates the maintenance of homeostasis, and regulates neutrophils, macrophages and pro-inflammatory signaling molecules in mucosal tissues.[19] Li research showed that high levels of FOXO-1 phosphorylation were related to the generation of IL-6, IL-1β, and TNF-α in macrophages of PCOS patients. This evidence concerns the gene FOXO1 and polycystic ovary syndrome.