TREM2 and polycystic ovary syndrome: The RT-qPCR results showed overexpression of CD163, TREM1, and TREM2 genes.[7] A large clinical study by Liu et al showed that overweight PCOS patients had higher CD68+ and CD163+ macrophage levels in their endometrium than normal women.[8] The number of immune cells in the endometrium of women with PCOS increased, resulting in a low-grade chronic inflammation condition.