The drug targets of Chuanxiong Rhizoma, Radix Angelicae Biseratae and Achyranthis Bidentatae Radix, and arthritis were imported into R software, and 41 targets were obtained with relevant tools; Using the CytoNCA plug-in to complete the PPT further topology, PTGS2, AKT1, CASP3, CAT, and SOD1 are the top 5 nodes in terms of degree values; gene ontology enrichment analysis obtained 1332 entries, including 1120 biological process entries, 112 cell composition entries, and 100 molecular functions. Here, AKT1 is linked to arthritic joint disease.