INS and Schnyder corneal dystrophy: Serum insulin level in SCD male mice was significantly lower than in sex-matched WT and SCT mice at 20 weeks of age compared to SCD males at 8 weeks of age (Fig. 3A), and was significantly lower in SCD female mice compared to sex-matched WT and SCT mice at 12, 16, and 20 weeks compared to SCD females at 8 weeks of age (Fig. 3B).