In a rat model of ischaemic brain injury, elevated levels of tRNA-Gly and tRNA-Val tsRNAs produced by angiogenin were predicted to negatively impact endothelial cell functions involved in angiogenesis, which would be disadvantageous in tissue repair processes.62 Finally, another example of a detrimental role for tsRNAs is the recent observation of accumulation of mitochondrial tRNA-Glu-derived tsRNAs in ageing neurons. The gene discussed is ANG; the disease is brain injury.