In mouse models of neurodegenerative diseases (ALS, FTD and PD), tsRNAs are dysregulated, with upregulation of specific 5′-tsRNAs produced by angiogenin in ALS models and downregulation of 3′-tsRNAs produced by Dicer in the TDP43A315T ALS and the TauP301S FTD models. The gene discussed is DICER1; the disease is frontotemporal dementia.