NOTCH2 and central nervous system cancer: For example, NOTCH2 is a known promoter of glioma growth and recently, a 3′-tsRNA derived from alanine-carrying tRNA (termed by the authors CAT1—‘cancer associated tsRNA 1’,) has been identified as a regulator of NOTCH2 signalling.84 Notably, CAT1 inhibits the degradation of NOTCH2 transcripts by binding to a specific RNA-binding protein with multiple splicing capacities (RBPMS), which facilitates tumour growth.84 Interference with the production of CAT1 or the tsRNA itself may therefore offer a therapeutic option and calls for further studies.