Although we do not formally show that depletion of other APOBEC3 proteins might impact virus cell-to-cell spreading in macrophages, our findings on APOBEC3G and the lack of Vif impact and IFN-I resistance, indicate that macrophage infection by cell-cell fusion escapes restriction by all IFN-stimulated APOBEC3 family members. The gene discussed is IFNA1; the disease is infection.