These centrosome components are critical for maintaining the head-tail attachment, as exemplified by the fact that mutation of centrosomal genes Cep112, Cep250, Cntrob, and Odf1, lead to acephalic spermatozoa (headless sperm) and non-obstructive azoospermia [30–35]. The gene discussed is CEP112; the disease is Azoospermia.