Immunoblotting showed that EV-D68 infection resulted in prominent PABPC1 cleavage bands at 60 kDa and 45 kDa, while transfection with 2Apro resulted in a cleavage band at 60 kDa and transfection with 3Cpro resulted in a band at 45 kDa, suggesting that both 2Apro and 3Cpro are involved in PABPC1 cleavage. Here, PABPC1 is linked to infection.