The second patient with autoimmune hemolytic anemia, that was accompanied by arthritis, (Ht: 22.0%, Hb: 7.2 g/dL) also improved after RTX treatment introduction (Ht: 32.3%, Hb: 9.5 mg/dL and Ht: 32.6%, Hb: 10.2 mg/dL at 1 yr and ≥ 10 yr, respectively). The gene discussed is GSTM1; the disease is autoimmune hemolytic anemia.