We have previously demonstrated that a thymus-dependent multiorgan autoimmune disease occurs in HIS mice generated by intravenous injection of human fetal liver (FL) CD34+ cells into NSG mice and that this disease develops more rapidly in mice containing a native murine thymus (termed ‘Mu/Hu mice’ [murine thymus/human CD34+ cells]) than in thymectomized (Khosravi-Maharlooei et al., 2020) NSG mice receiving a human thymus graft, termed ‘Hu/Hu mice’ (human thymus/human CD34+ cells) (Khosravi-Maharlooei et al., 2021). The gene discussed is CD34; the disease is autoimmune disease.