In Drosophila, Tribbles mediates Hippo pathway-regulated tumor growth (Gerlach et al., 2019), and mammalian Trib1 and Trib2 act as either oncogenes or tumor suppressors depending on the tissue context (Gilby et al., 2010; Wang et al., 2013a; Liang et al., 2013; Miyajima et al., 2015; Li et al., 2020; Salomé et al., 2018; Hong et al., 2019; Qu et al., 2019; Singh et al., 2024; Fang et al., 2021; Stefanovska et al., 2021; reviewed by Mayoral-Varo et al., 2021; Ferreira et al., 2021; McMillan et al., 2021; Arif et al., 2023). The gene discussed is TRIB2; the disease is neoplasm.