The ability of TrblSLE/G to increase the stability of three Trbl degrons – Slbo (C/EBP; Fig. 5H), String (Cdc25 phosphatase; Fig. 5J) and Trbl (Fig. 4E) – indicates that the SLE/G mutation dominantly increases the stability of a wide range of Trbl targets during development; in support of this, R4-GAL4 fat body-specific expression of TrblSLE/G led to decreased larval mass, cell size and delayed pupation compared to WT Trbl (Fig. S5G,H). Here, CD1A is linked to systemic lupus erythematosus.