In mammals, Trib2 dimers have been documented (Jamieson et al., 2022) and we have previously demonstrated that Trbl–Trbl interactions occur in Drosophila (Masoner et al., 2013), so we tested the notion that the SLE/G mutation stabilizes Trbl hetero-multimers in several ways. The gene discussed is TRIB2; the disease is systemic lupus erythematosus.