Meanwhile, considering that diabetes will result in severe complications and that insulin has been indicated to play an important role in controlling the progression of diabetic complications such as retinopathy, neuropathy, and nephropathy, medications that combine insulin with other therapeutic agents, like liraglutide and manganese dioxide nanoenzyme, to improve the treatment effectiveness are also reported [9,10,11,12]. The gene discussed is INS; the disease is Nephropathy.