As outlined previously, key contributing authors, such as González-Castro A.M., in collaboration with Vicario M., Lobo B., and Martínez C., have demonstrated that grape seed extract, which is rich in polyphenols, reduces visceral hypersensitivity in IBS models by suppressing TLR4-cytokine signaling while preserving tight junction integrity [62]. Here, TLR4 is linked to irritable bowel syndrome.