In a rat model of reflux esophagitis (RE), Flos Lonicerae (LF) decreased esophageal and gastric mucosal lesions, lipid peroxidation, and collagen accumulation, and enhanced antioxidant indicators such as SOD, CAT, and GSH just like α-tocopherol [147]. The gene discussed is SOD1; the disease is gastroesophageal reflux disease.