1. Eleven cuproptosis related genes associated with RA were identified, including DLST, LIAS, DLAT, DLD, PDHB, LIPT1, DBT, ATP7B, SLC31A1, FDX1, and PDHA12. PDHB protein levels were significantly reduced in CIA model rats3. PDHB may play an important role in RA development. This evidence concerns the gene DBT and rheumatoid arthritis.