1. Copper ions promote cancer cell proliferation, angiogenesis and metastasis by activating various signaling pathways (such as RTK, PI3K-AKT, MAPK, etc.)2. In a variety of tumors, the expression level of CRGs is closely related to the prognosis of patients3. In hepatocellular carcinoma, high expression of CDKN2A is associated with a worse prognosis. This evidence concerns the gene AKT1 and hepatocellular carcinoma.