CIAO2A and rheumatoid arthritis: 1. In RA patients, 7 out of 13 CRGS showed significantly increased expression levels, while DLST expression levels were significantly decreased2. These differentially expressed CRGS are strongly implicated in the pathogenesis of RA.3. The important role of these genes in RA was further supported by the significantly increased expression levels of five predicted genes (FAM96A, MAK4P3, PRPF39, SLC35A1, TMX1) validated by qRT-PCR in the animal model of RA.