CDKN2A and neoplasm: In an aggressive transplanted Eμ-myc Arf−/− mice model (Burkitt’s lymphoma), where Eμ regulates the overexpression of c-myc and knockout of Arf leads to p53 inactivation, T cells functionalized with SN-38 NCs rapidly reduced tumor burden in several anatomical regions and dramatically extended survival compared to systemic chemotherapy.