As such, nano-aAPC made of dextran-coated paramagnetic iron oxide NPs coupled with MHC/HLA-A-0201 (an antigen of MART-1) and anti-CD28 enriched MART-1-specific CD8+ T cells up to 1000-fold after 14 days of treatment and expanded cell populations with a memory phenotype expressing CD45RA, CD62L, CD95, as well as longer telomeres compared to unexpanded T cells, as shown by Junya Ichikawa and collaborators investigating melanoma cell lines.81 The gene discussed is CD8A; the disease is melanoma.