Cytokines and growth factors (such as IL-6 (Interleukin-6), IL-8 (Interleukin-8), and VEGF (vascular endothelial growth factor)) contained in SASPs not only promote tumor angiogenesis but also attract immune-suppressor cells, such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), which protect tumor cells from the immune system. Here, IL6 is linked to neoplasm.