found that SIRT1 synergistically regulates pancreatic cancer stem cell properties and promotes tumorigenesis with the CRL4B (Cullin 4B (CUL4B)-Ring E3 ligase) (87), in which SIRT1/CUL4B promotes a variety of CSC (cancer stem cell) properties, including increased expression of stemness marker expression and sphere formation, and could also be a potential target for tumor immunotherapy. This evidence concerns the gene CUL4B and cancer.