Transcriptome analysis of NAFLD-driven hepatocellular carcinoma patients showed that LINC01468 expression was significantly upregulated; LINC01466 is a long non-coding RNA that promotes the progression of NAFLD to HCC by binding to CUL4A and SHIP2, thereby inducing SHIP2 degradation through ubiquitination. The gene discussed is CUL4A; the disease is metabolic dysfunction-associated steatotic liver disease.