ACACA and fatty liver disease: This inhibition leads to downregulation of mRNA levels of SIRT6 target genes ACC1, SCD1, FAS, and CRFVL6, and reduced serum inflammatory factors TNF-α, IL-1β, IL-4, IL-6, IL-2, and chemokine MCP-1, which in turn attenuates hepatic steatosis and inflammation in HFD mice (78).