Transcriptome analysis of NAFLD-driven hepatocellular carcinoma patients showed that LINC01468 expression was significantly upregulated; LINC01466 is a long non-coding RNA that promotes the progression of NAFLD to HCC by binding to CUL4A and SHIP2, thereby inducing SHIP2 degradation through ubiquitination. This evidence concerns the gene INPPL1 and metabolic dysfunction-associated steatotic liver disease.