SREBF1 and metabolic dysfunction-associated steatotic liver disease: CUL4B-DDB1 inhibits the activation of the mTORC1 signaling pathway by interacting with Raptor and promoting the polyubiquitination of its K48 linkage, an effect that leads to the down-regulation of the expression of genes related to adipogenesis, oxidation, lipid uptake, and secretion (such as, SREBP1, PPARα, CD36, APOE), which attenuates hepatic steatosis in NAFLD (53).