The combination of anti-COPT1-IgG, anti-COPT1-IgM, and CEA enhanced the efficacy of NSCLC diagnosis from BPN, and the AUC value increased up to 0.670 (95% CI: 0.603-0.737) (Figure 10B, Table 4). This evidence concerns the gene CD40LG and non-small cell lung carcinoma.