The AUCs of anti-COPT1-IgG and anti-COPT1-IgM autoantibodies for distinguishing NSCLC from NC were 0.885 (95% CI: 0.834-0.937, sensitivity=86.5%, specificity=82.0%) and 0.921 (95% CI: 0.883-0.958, sensitivity=88.8%, specificity=82.0%), respectively (Figures 3C, D). This evidence concerns the gene CD40LG and non-small cell lung carcinoma.