The AUC values of anti-COPT1-IgG and anti-COPT1-IgM to distinguish NSCLC from BPN in females was 0.720 (95% CI: 0.655-0.784, sensitivity=60.7%, specificity=74.4%) and 0.682 (95% CI: 0.615-0.749, sensitivity=86.9%, specificity=47.1%), respectively (Supplementary Figures 4A, B). Here, CD40LG is linked to non-small cell lung carcinoma.