For female individuals, the AUC values of anti-COPT1-IgG and anti-COPT1-IgM autoantibodis for distinguishing NSCLC from NC were 0.801 (95% CI: 0.747-0.855, sensitivity=53.3%, specificity=94.1%) and 0.808 (95% CI: 0.755-0.861, sensitivity=64.8%, specificity=82.2%), respectively (Supplementary Figure 4). The gene discussed is CD40LG; the disease is non-small cell lung carcinoma.