Although sudden withdrawal of estrogen affects the autonomic nervous system, it can lead to the development of neurodegenerative diseases (Balan et al., 2020), interestingly, FSH blockade has been shown to improve cognition in mice with Alzheimer's disease (Xiong et al., 2022), and genetic ablation of LH receptors has been found to reduce amyloid pathology in mice with Alzheimer's pathology (Lin et al., 2010). Here, BRD2 is linked to Alzheimer disease.