Considering that injection of RJ might increase the rate of LH and FSH hormone secretion (Moghaddam et al., 2013), the present study evaluated the possible effects of RJ pretreatment on the LH and FSH hormone levels, as well as hippocampal neurons in a pentylenetetrazole (PTZ)-induced seizure model of ovariectomized (OVX) rats. The gene discussed is PLOD1; the disease is Seizure.