Our results suggest that monokine induced by gamma interferon (MIG) and interleukin-10 (IL-10) may act as risk factors for MZL, while brain-derived neurotrophic factor (B-NGF) could serve as a protective factor against MZL Reverse MR analysis excluded MIG, IL-10, and B-NGF as downstream molecules of MZL. This evidence concerns the gene IFNG and marginal zone lymphoma.