Previous studies have demonstrated that YAP may exert some control over the PI3K/Akt pathway (McLoughlin, Mueller & Grossmann, 2018) and that activated YAP stimulates the PI3K/Akt pathway, promotes the proliferation and activity of vascular endothelial cells, and regulates the growth of synovial arteries in mouse RA and the inflammatory process in RA joints. This evidence concerns the gene YAP1 and rheumatoid arthritis.