Du et al. (2022) reported that knockdown of VGLL3 increased TAZ expression but had no effect on YAP expression in RA-FLSs. On the other hand, TAZ expression was suppressed by VGLL3 overexpression. Furthermore, VGLL3 activates the Hippo pathway and promotes the proliferation of A549 cells and MDA-MB-231 cells (Hori et al., 2020). The gene discussed is VGLL3; the disease is rheumatoid arthritis.