The DE50-MD dog is a more recently developed canine model, and in contrast to the GRMD and CXMDJ models, the causative mutation in DE50-MD dogs lies within the human mutation “hotspot” region of the dystrophin gene and is amenable to exon 51 skipping or gene editing6, approaches that are applicable to the largest proportion of DMD patients5. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.