In a cohort of 4,665 DLBCL patients, XPO1 overexpression was found to be overrepresented in the resistant/relapsed subgroup, and interestingly, XPO1 expression was negatively correlated with IFNγ signaling, suggesting dysfunctional or reduced frequency of immune cells within the tumour microenvironment (TME) [8]. This evidence concerns the gene XPO1 and neoplasm.