DDC and aromatic L-amino acid decarboxylase deficiency: For example, fluoxetine has been used in aromatic L-amino acid decarboxylase (AADC) deficiency [36] because it binds with high-affinity to the serotonin transporter, inhibiting reuptake inhibition of synaptic serotonin and enhancing neurotransmission with minimal effects on norepinephrine and dopamine uptake, and displaying minimal binding to postsynaptic receptors [37,38].