In contrast, CAR crosstalks with peroxisome proliferator-activated receptor (PPAR) (174), and this crosstalk may allow bilirubin to reduce the incidence of nonalcoholic steatohepatitis through the interaction between CAR and PPAR (175), which in turn reduces the incidence of HCC. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.