The results suggest that bilirubin exerts a protective effect in intrinsic immune-related inflammation at certain doses by a mechanism associated with the NF-κB signaling pathway inhibition and the NOD-like receptor family CARD domain-containing protein 4 (NLRC4) activation, Absent in Melanoma 2 (AIM2), and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammatory vesicles, of which the inhibition contributes to the control of cancer (92–94). This evidence concerns the gene NFKB1 and cancer.