In contrast, CAR crosstalks with peroxisome proliferator-activated receptor (PPAR) (174), and this crosstalk may allow bilirubin to reduce the incidence of nonalcoholic steatohepatitis through the interaction between CAR and PPAR (175), which in turn reduces the incidence of HCC. This evidence concerns the gene NR1I3 and metabolic dysfunction-associated steatohepatitis.