INS and diabetes mellitus: In total, the levels of 158 metabolites were significantly lower in the CTR group than the anti-DM group (p < 0.05) (Figure 4D and Supplementary Table S1), and significantly enriched in 38 KEGG pathways, such as “Regulation of lipolysis in adipocytes,” “Glycerolipid metabolism,” “Fat digestion and absorption,” “Insulin secretion,” and “Insulin signaling pathway” (p < 0.05) (Supplementary Figure S6C).