FOXO1 and Cerebral ischemia: In addition, Maorui isoflavone glycoside acts on neuronal cells after cerebral ischemia-reperfusion, upregulating Sirt1, FOXO1, PGC-1ɑ, and Bcl-2, while downregulating Bax, indicating that the flavonoid glycoside alleviates neuronal apoptosis and oxidative stress through the Sirt1/FOXO1/PGC-1ɑ signal pathway [24].