As illustrated in Fig. 9, three distinct tumor regions, normoxic, hypoxic, and necrotic are defined in panel A. Panel B highlights epithelial cells co-expressing E-cadherin and β-catenin, which localize predominantly within normoxic areas, while panel C shows “Hypoxic_PIMO-dim” cells enriched in hypoxic and necrotic regions. This evidence concerns the gene CDH1 and neoplasm.