Notably, TNF and AXIN1 showed a significant increase in inflamed (1.37 and 0.52 increase in mean NPX, respectively) and non-inflamed IBD (1.17 and 0.6 increase in mean NPX, respectively) compared to non-IBD controls, suggesting that these markers may serve as effective biomarkers for IBD, irrespective of the disease activity status, whether it is active or in remission. This evidence concerns the gene TNF and inflammatory bowel disease.