The Notch pathway inhibitor DAPT alleviated nab-PTX-evoked pain, including mechanical allodynia and thermal hypersensitivity, spinal cord apoptosis, glial response, oxidative stress, and microtubule and axonal damage, in a rat PTX-induced peripheral neuropathy model by protecting vascular integrity and decreasing the levels of proinflammatory cytokines in vivo and in vitro via the Notch/HMGB1/caveolin-1 pathway. This evidence concerns the gene HMGB1 and peripheral neuropathy.