STING1 and chronic obstructive pulmonary disease: M335 shows micromolar binding affinity toward STING, activates the STING-TBK1-IRF3 in an STING-dependent manner, and inhibits the growth of multiple refractory cold tumors (MC38, CT26, and B16-F10) administered even intraperitoneally at a 20-mg/kg level.82