Although its etiology is not fully understood, recent evidence has highlighted the importance of type-2 inflammation in the pathogenesis of CRSwNP.1, 2Type-2 inflammation is clinically significant due to its close association with chronic inflammatory conditions (such as asthma and atopic dermatitis) and higher rates of revision surgery.3, 4Hence, there has been a growing interest in monoclonal antibody biologics targeting the type 2-inflammatory cascade, including mepolizumab (anti-IL-5), omalizumab (anti-IgE), and dupilumab (anti-IL-4Rα). The gene discussed is IGHE; the disease is asthma.