ENaC, epithelial sodium channels; Na+, sodium channel; K+, potassium channel; ICF, intracellular fluid; ECF, extracellular fluid; MAOIs, monoamine oxidase inhibitors; SSRIs, selective serotonin reuptake inhibitors; SNRIs, serotonin-norepinephrine reuptake inhibitors; TCAs, tricyclic antidepressants; SIADH, syndrome of inappropriate antidiuretic hormone; HDAC, histone deacetylase; MAPK, mitogen-activated protein kinase. This evidence concerns the gene XK and inappropriate ADH syndrome.