Na+, sodium; K+, potassium; CCBs, calcium channel blockers; KATP, ATP-sensitive potassium channel; COX-2, cyclooxygenase-2; TMP-SMX, trimethoprim-sulfamethoxazole; ENaC, epithelial sodium channel; KI, potassium iodide; KOR, kappa opioid receptor; TLS, tumor lysis syndrome. The gene discussed is PSME3; the disease is Tumor Lysis Syndrome.