EGFR and chronic obstructive pulmonary disease: EGFR prevents TRPM 6/7 ion channels from reaching the apical membrane of the distal tubule, regulating magnesium reabsorption. These medications inhibit apical TRPM ion channels through EGFR blockade, leading to hypomagnesemia and renal magnesium wasting, which may result in hypokalemia and cardiac arrhythmias.