Hypertensive heart disease, which is treated with antihypertensive RAAS inhibitors such as angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs), is likely to have reversible interstitial fibrosis as these medications aim to reduce myocardial fibrosis and improve left ventricular function. This evidence concerns the gene ACE and Myocardial fibrosis.