CDKN2A and oropharynx cancer: Risk factors for oral and oropharyngeal cancers include oral HPV infection (linked to practices like oral sex and open-mouthed kissing) [6,7,8], whereas less common risk factors include tobacco smoking, alcohol consumption, poor diet, betel quid chewing, exposure to factors like asbestos, and mutations in genes such as P53 and CDKN2A (p16) [9].