CXCR4 and breast cancer: Sinusoidal tropism in breast cancer cells is facilitated by chemokine receptors such as CXCR4 and CCR7, which mediate chemotaxis toward their ligands CXCL12 and CCL21, respectively, and adhesion molecules like E-selectin and CD44, which enhance cell adhesion and migration under physiological flow conditions [11,12]. Liver metastasis typically presents as multiple distinct hypovascular or hypervascular masses; it is rare for it to present as diffuse infiltrating neoplasms that are undetected in radiologic evaluation studies [13].