More specifically, Guy et al., [17] conducted a prospective and larger study, with a sample of 7720 pregnant women, including in the screening method the maternal characteristics, MAP, PAPP-A, and UtA - PI, showed that for preeclampsia before 37 weeks the NICE method had 36.9% sensitivity with 84.1% specificity while the combined method with cutoff 1 in 100 had a sensitivity of 70.4% with a sensitivity of 81.9%. This evidence concerns the gene PAPPA and preeclampsia.