CRTC1 and neoplasm: Similar to that of HCCC, immunostaining of p40 and p63 was positive, while αSMA, calponin, and s-100 protein were negative. Recently, the CAMP-regulated transcriptional coactivator 1/3 (CRTC1/3)-mastermind-like transcriptional coactivator 2 (MAML2) fusion gene was found to be positive in 80% of MECs, and the EWSR1-ATF1 fusion gene was positive in over 90% of HCCC, which is a differentiating feature. Localization of the primary tumor also helps to differentiate HCCC from MEC, as most HCCC tumors tend to be located in the minor salivary glands of the oral cavity [6].