In our previous studies, we were ableto show that Sarcopoterium spinosum root extract (SSE) can alleviateelevated blood glucose levels in mouse models of glucose intolerance.11−13 This was achieved either by enhancing insulin sensitivity or bymimicking the effect of the hormone.14,15 Our previousstudies also demonstrated that SSE stimulated the transmission ofthe insulin signaling cascade in L6 and 3T3-L1 adipocytes. Here, INS is linked to Glucose intolerance.