PPARA and steatosis: Chronic alcohol consumption is directly associated with steatosis(fatty degeneration in hepatocytes), steatohepatitis (when steatosisis associated with inflammation), fibrosis, and hepatocellular carcinoma(HCC).21 Steatosis is the first sign ofhepatic injury, and it is caused both by acetaldehyde and unbalancingexpression of SREBP and PPAR-α.21 The main histomorphology characteristic of steatosis is the balloonedhepatocytes filled by lipids vesicles.