We further screened the candidates showing more than 2-fold upregulation in other lung cancer cell lines, H1975 (L858R and T790 M EGFR mutation) and PC9 (delR746-A750 EGFR mutation) cells treated with 100 nM osimertinib, and identified HDAC5, one of histone deacetylases (Figs. S1C, S1D, 1B, and 1C). The gene discussed is HDAC5; the disease is lung cancer.