We further screened the candidates showing more than 2-fold upregulation in other lung cancer cell lines, H1975 (L858R and T790 M EGFR mutation) and PC9 (delR746-A750 EGFR mutation) cells treated with 100 nM osimertinib, and identified HDAC5, one of histone deacetylases (Figs. S1C, S1D, 1B, and 1C). This evidence concerns the gene EGFR and lung cancer.