KDR and cancer: Pyrazole derivatives have emerged as a promising class of compounds in cancer research due to their diverse biological activities, including anti-cancer properties.53,54 Many pyrazole derivatives can trigger cancer cells that undergo programmed cell death, promoting apoptosis and thereby reducing tumor size and preventing metastasis.52,55 Some pyrazole derivatives function as kinase inhibitors, targeting specific enzymes involved in tumor growth and survival, such as EGFR, VEGFR, and CDK.