Overexpression of TOP2A is observed in multiple types of cancer, such as lung, breast, and liver cancer, and it is linked to tumor progression, chemoresistance, and resistance to radiotherapy (Sritharan and Sivalingam, 2021; Glisson and Ross, 1987; Chen et al., 2024; Jiang et al., 2024). The gene discussed is TOP2A; the disease is liver cancer.