Another, in an animal experiment on N-Nitrosodimethylamine (NDMA)-induced pulmonary fibrosis, ascorbic acid was observed to significantly reduce P53, caspase-3, Bax (which inhibits the anti-apoptotic effect of Bcl-2) and Bax/Bcl-2 ratio in lung tissue, while increasing Bcl-2 and mdm2 levels, thereby exerting anti-apoptotic properties (84). This evidence concerns the gene BAX and pulmonary fibrosis.