Next, SVM-RFE analysis selected 12 genes (PTGER4, YAL2, PTGER2, ALOX5, PLA2G4A, PTGS1, IDO1, LMNB1, IL1B, SGPP1, PLK2 and PRKCB) as highly correlated with LN (Figure 5C). This evidence concerns the gene PRKCB and lobular neoplasia.