Next, SVM-RFE analysis selected 12 genes (PTGER4, YAL2, PTGER2, ALOX5, PLA2G4A, PTGS1, IDO1, LMNB1, IL1B, SGPP1, PLK2 and PRKCB) as highly correlated with LN (Figure 5C). The gene discussed is PTGER4; the disease is lobular neoplasia.