Genes belonged to the Top10 Mean Decrease Accuracy ranking list and the Top10 Mean Decrease Gini ranking list were judged as important genes related to LN, which made up 9 (PLA2G4A, PTGER2, HYAL2, PTGS1, ALOX5, RPS6KA3, PRKCB, EZH2 and MAP4K4). This evidence concerns the gene HYAL2 and lobular neoplasia.