Several studies reported that in mesenchymal stem cells (MSCs) from SLE patients, signaling pathways including PI3K/Akt, PTEN/Akt, JAK-STAT, p53/p21, and Wnt/beta-catenin are activated in the development of the senescence phenotype (Li et al., 2021). Here, TP53 is linked to systemic lupus erythematosus.