In this study, we combined rs1045642, rs1371097, and relevant clinical factors (including age, gender, history of diabetes, history of cerebral infarction, TOAST classification, admission NIHSS score, fasting blood glucose, red blood cells, CRP, neutrophils, lymphocytes) to construct a relatively reasonable molecular prediction model, which showed a higher predictive efficacy for adverse outcomes of stroke compared to single factors. This evidence concerns the gene CRP and stroke disorder.