Yuanyuan Zhong et al. discovered that Bu-Shen-Yi-Qi Decoction improves chronic obstructive pulmonary disease-related osteoporosis by upregulating genes related to antioxidant stress and aerobic respiration and activating the MAPK and PI3K/AKT pathways (Zhong et al., 2023). This evidence concerns the gene AKT1 and osteoporosis.