A retrospective study from South Korea of early onset epileptic encephalopathy showed that treatment response to drugs as well as KD varied according to genetic aetiology.11 In another study, 155 children treated with KD were examined with a gene panel of 72 genes for epileptic encephalopathy and a pathogenic variant was verified in 73 children (47.1%).12 Causative variants in STXBP1 were associated with a high responder rate while variants in other genes had a lower KD response. This evidence concerns the gene STXBP1 and Epileptic encephalopathy.